MEDX

ImagenMD® with Cedars-Sinai QGS and QPS is an interactive standalone nuclear medicine processing application for the automatic segmentation, quantification, analysis and display of static and gated short axis myocardial perfusion SPECT at the office, hospital or home. The system also has databases (purchased by the user) for quantifying the extent and severity of myocardial defects.

Publications

• Germano G, Kavanagh P, Waechter P, Areeda J, Sharir T, Lewin H, Berman D. A new automatic approach to myocardial perfusion SPECT quantitation. J Nucl Med 1998 (abstract); 39(5):62P.
• Lewin H, Sharir T, Germano G, Kavanagh P, Lai S, Friedman J, Kang X, Berman D. Reproducibility of dual isotope myocardial perfusion SPECT using a new quantitative perfusion SPECT (QPS) approach. J Am Coll Cardiol 1999 (abstract); 33(2(Suppl.A)):483A.
• Sharir T, Germano G, Kavanagh P, Areeda J, Lewin H, Friedman J, Berman D. A novel method for quantitative analysis of myocardial perfusion SPECT: validation and diagnostic yield. J Nucl Med 1998 (abstract); 39(5):103P.

QPS provides the following functionality:

• Automatic generation of left ventricle (LV) inner and outer surfaces and valve plane from LV short axis perfusion SPECT data, using user supplied hints if available (e.g. approximate LV location).
• Display of stress and rest projection (raw) images in static and cine mode. Two-dimensional display of stress and rest short axis SPECT images in 1 (single), 2 (dual), 3 (triple), or 4 (quadruple) mode. (2, 3, and 4 are displayed as interleaved or side-by-side). Three-dimensional parametric display of stress and rest short axis SPECT images in 1 (single), 2 (dual), 3 (triple), or 4 (quadruple) mode. (2, 3, and 4 are displayed as interleaved or side-by-side).
• Automatic computation of functional metrics including LV chamber volume and mid-myocardial surface area
• Automatic generation of stress, rest and reversibility surfaces and polar maps, which display in parametric fashion the pattern of LV myocardial perfusion. Determination and display of the severity and extent of perfusion defects using isotope- and gender-specific normal limits.
• Automatic computation of global quantitative defect size, both in absolute terms and as a percentage of the mid-myocardial surface area.
• Automatic generation of segmental perfusion scores (stress, rest and reversibility) based on a multi-segment, multiple-point scale, and subsequent derivation of the global scores SSS (summed stress score), SRS (summed rest score), SDS (summed difference score), SS% (summed stress percent), SR% (summed rest percent), and SD% (summed difference percent).
• Display of screen captures images (also known as snapshots).
• Storage of all generated results in a separate review file.